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Feature•Jun 23, 2026

AWS HealthOmics now supports ephemeral storage for private workflows

AWS HealthOmicsAWS · Machine Learning

AWS HealthOmics adds ephemeral storage for private workflows, giving bioinformatics workloads dedicated scratch space that delivers more consistent run performance and lower costs. Each workflow task now receives a dedicated local volume mounted at /tmp, and workflows that generate significant scratch data, such as genomic sequence alignment, BAM sorting, and variant calling, can experience faster run times. AWS HealthOmics is a HIPAA-eligible service that helps healthcare and life sciences customers accelerate scientific breakthroughs with fully managed bioinformatics workflows.

With this launch, workflow tasks can write temporary data to their own local volume, keeping scratch I/O isolated from shared run storage that hosts the working directory. By default, each task includes 16 GiB of ephemeral storage at no additional charge. You can increase the amount of ephemeral storage allocated to individual tasks, up to a maximum of 3,072 GiB per task, using the appropriate directive in your WDL, Nextflow, or CWL workflow definition. You can enable ephemeral storage at runtime with the StartRun API. All ephemeral storage volumes are encrypted and deleted when a task terminates.

You can use ephemeral storage in all AWS Regions where AWS HealthOmics is available: US East (N. Virginia), US West (Oregon), Europe (Frankfurt, Ireland, London), Israel (Tel Aviv), and Asia Pacific (Singapore, Seoul). To learn more about ephemeral storage, visit the AWS HealthOmics User Guide. For more information on pricing, visit AWS HealthOmics pricing.

Read the original announcement↗

More from AWS HealthOmics

All AWS HealthOmics updates →
  1. AWS HealthOmics now supports IAM session policies

    AWS HealthOmics now supports IAM session policies, enabling you to restrict permissions for individual runs without creating and managing multiple IAM roles.

    AWS HealthOmics•Feature•Sep 17, 2026
  2. AWS HealthOmics now publishes real-time run metrics to Amazon CloudWatch

    AWS HealthOmics now publishes real-time run metrics to Amazon CloudWatch, giving you visibility into workflow resource utilization as runs execute.

    AWS HealthOmics•Feature•Sep 11, 2026
  3. AWS HealthOmics introduces resource fallback order for WDL workflows

    Today, AWS HealthOmics introduces the resource fallback directive, enabling you to define an ordered list of preferred accelerator types, including an option to fallback to CPU instances, for tasks in your Workflow Description Language (WDL) workflows.

    AWS HealthOmics•Feature•Sep 8, 2026
  4. AWS HealthOmics now supports task-level timeout for WDL workflows

    AWS HealthOmics now supports task-level timeout for Workflow Description Language (WDL) workflows, enabling you to set maximum execution duration for individual tasks.

    AWS HealthOmics•Feature•Aug 3, 2026
  5. AWS HealthOmics now available in two additional AWS Regions

    AWS HealthOmics private workflows are now available in the Asia Pacific (Tokyo) and US East (Ohio) Regions, expanding access to fully-managed bioinformatics workflows for research, drug discovery, and agriculture science initiatives with regional compliance requirements.

    AWS HealthOmics•Region•Jul 20, 2026